The aging mouse brain: cognition, connectivity and calcium

Aging is a complex process that differentially impacts multiple cognitive, sensory, neuronal and molecular processes. Technological innovations now allow for parallel investigation of circuit function, structure composition in the brain awake behaving adult mice. Thus, mice have become critical tool to better understand how aging brain. However, more granular systems-based approach, which considers impact age on key features relating neural processing, required. Here, we review evidence probing mouse We focus range processes including cognitive abilities, sensory systems, synaptic plasticity calcium regulation. Across many find prominent age-related dysregulation even before 12 months age, suggesting emerging alterations can manifest by late adulthood. also reports some are remarkably resilient aging. The suggests does not drive parallel, linear all but instead earlier, severely, than others. propose capturing fine-scale vulnerability resilience may provide opportunities rejuvenation aged